REACTION OF ISONIAZID (INH) WITH RHENIUM (Re) USING DIFFERENT REDUCING AGENTS, CHARACTERIZATION OF COMPLEXES AND X-RAY CRYSTAL STRUCTURE OF INH DIMER

Authors

  • N. Amir Isotope Production Division, PINSTECH, P.O. Nilore, Islamabad, Pakistan
  • S. Roohi Isotope Production Division, PINSTECH, P.O. Nilore, Islamabad, Pakistan
  • S. Pervez Isotope Production Division, PINSTECH, P.O. Nilore, Islamabad, Pakistan
  • M. Jehangir Isotope Production Division, PINSTECH, P.O. Nilore, Islamabad, Pakistan
  • Y. Miyashita Department of Chemistry, University of Tsukuba, 305-8571, Japan

Abstract

Reactivity of INH with NH4ReO4 was studied using SnCl2•2H2O and NaBH4 as reducing agents. 99mTc labelled INH was also prepared according to the reported procedure for comparison. A complex (1) similar to 99mTc-INH (2) was formed with NH4ReO4 in the presence of SnCl2•2H2O. On the other hand, NaBH4 gave a dimer of INH (3) which was confirmed by x-ray crystallography. The products, 1, 2 and 3 were characterized by HPLC, IR spectra and x-ray crystallography.

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Published

01-07-2020

How to Cite

[1]
N. Amir, S. Roohi, S. Pervez, M. Jehangir, and Y. Miyashita, “REACTION OF ISONIAZID (INH) WITH RHENIUM (Re) USING DIFFERENT REDUCING AGENTS, CHARACTERIZATION OF COMPLEXES AND X-RAY CRYSTAL STRUCTURE OF INH DIMER”, The Nucleus, vol. 45, no. 3-4, pp. 143–148, Jul. 2020.

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